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KMID : 1123920060200030651
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Korean Journal of Oriental Physiology and Pathology
2006 Volume.20 No. 3 p.651 ~ p.656
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Relationship of Inhibitory Effects of Dichroa febrifuga and IKKγ on the Activation of NF-κB
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Choi Byung-Tae
Lee Yong-Tae
Hwang Jang-Sun
Moon Hae-In
Lee Kyung-Soo
An Won-Gun
Kim Dong-Wan
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Abstract
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Activation of is known to be a trigger of various cellular disorders including inflammatory and autoimmune diseases such as rheumatoid arthritis. Numerous approaches are ongoing within laboratories to identify potential therapeutic agents which inhibit the activation. In this study, we have tested the inhibitory effects of five traditional medicines on the activation of by NIK. Among three medicines which exhibited inhibitory effect on the expression of repoter plasmid, we investigated further the inhibitory mechanism of Dichroa febrifuga in connection with IKKY activity. Wild type inhibited the activation by NIK but the C-terminal deletion mutant of IKKY did not show the inhibitory effect, indicating that the C-terminal leucine zipper domain of is important for the inhibition of activation. The water extract of Dichroa febrifuga(DFE) also strongly inhibited the activation by NIK. The inhibitory activity of DFE appeared to be independent of the expression of , suggesting that the pathways of inhibition by Dichroa febrifuga and are different. Our results suggest that Dichroa febrifuga can be used as a medicine for inhibition of the activation in a wide range of cells without relation to the expression of .
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KEYWORD
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Dichroa febrifuga, activation, NIK
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